Mebendazole is an effective antihelminthic drug commonly used to treat intestinal worm infections such as roundworms, hookworms, whipworms, and pinworms. Its primary mechanism of action involves inhibiting the worms’ ability to absorb glucose, which is essential for their survival. Specifically, mebendazole binds to the β-tubulin protein in the worm’s cells, disrupting the formation of microtubules. Microtubules are crucial for various cellular processes, including nutrient uptake, intracellular transport, and reproduction. By impairing microtubule synthesis, Mebendazole 100mg effectively prevents the worm from absorbing glucose from the host’s intestines.As a result, the worms experience energy depletion, leading to immobilization and eventual death. Mebendazole’s poor systemic absorption ensures that it acts primarily within the intestinal lumen, where the worms reside, minimizing systemic side effects in humans. After the worms die, the body naturally eliminates them through feces.
Additionally, mebendazole’s effect on the reproductive system of worms reduces egg production, helping to limit the spread of infection and prevent reinfestation. Its broad-spectrum activity, coupled with minimal toxicity in humans, makes mebendazole a widely prescribed and safe medication for controlling intestinal helminth infections.
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Additionally, mebendazole’s effect on the reproductive system of worms reduces egg production, helping to limit the spread of infection and prevent reinfestation. Its broad-spectrum activity, coupled with minimal toxicity in humans, makes mebendazole a widely prescribed and safe medication for controlling intestinal helminth infections.
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